During the 1940's, Macclenny's first full time physician, Dr. John Watson suggested to Paul Rhoden that he convert his sundry store into an official drug store to provide prescriptions locally.
He also encouraged the young Mr. Rhoden to attend pharmacy school at the University of Florida in Gainesville.
Paul's Rexal continued operating in Macclenny until 1993.
The museum contains items that chronicle the county's medical history from the yellow fever epidemic in the late 1880s to local midwives, physicians and nurses to the development of the health department and establishment of the local hospital. Dr. Watson's original appointment books, some prescriptions and medical records and his personal book of cure-all home remedies are among the collection.